NIH R01 — Significance & Innovation
NIH's standard investigator-initiated project grant. Since 2025 reviewers score two factors, Importance of the Research (Significance and Innovation) and Rigor and Feasibility (Approach), and check expertise and resources for sufficiency.
Scheme details
- Funding range
- No budget cap in the parent R01; modular budgets up to $250,000 a year in direct costs, detailed budgets above that; up to 5 years. Foreign organisations use a detailed budget, with F&A limited to 8%
- Career stage
- All career stages
- Scheme type
- Individual
- Eligibility
- Any investigator whose organisation supports the application; no citizenship or career-stage rule, and multiple PIs are allowed. Foreign organisations, including Australian universities, may apply to the parent R01, but foreign subawards are not allowed. At most six NIH applications per PI per calendar year.
- Format & limits
- Specific Aims: 1 page; Research Strategy (Significance, Innovation, Approach): 12 pages; Project Summary: 30 lines; Project Narrative (public health relevance): at most three sentences
- Deadline
- Open now Standard R01 dates: 5 February, 5 June, 5 October (new); 5 March, 5 July, 5 November (renewal, resubmission) · next: 5 October 2026 · PA-25-301 expires 8 January 2028
View official scheme page
https://grants.nih.gov/grants/guide/pa-files/PA-25-301.html
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Last updated: 2026-09-24
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