NIH R01 — Significance & Innovation
The standard NIH investigator-initiated research grant. Significance and Innovation are two of the five scored review criteria, alongside Approach, Investigator(s), and Environment.
Scheme details
- Funding range
- Up to $250,000/year direct costs (modular budget) · detailed budget for larger requests · typically 3–5 years
- Career stage
- All career stages
- Scheme type
- Individual
- Eligibility
- US-based institutions; investigators of any career stage and citizenship. Multiple-PI option available. Must have NIH eRA Commons account.
- Format & limits
- Public Health Relevance Statement: 2–3 sentences · Research Strategy (Significance, Innovation, Approach): up to 12 pages
- Deadline
- Open now Standard R01 receipt dates: Feb 5, Jun 5, Oct 5 (new) · Mar 5, Jul 5, Nov 5 (renewal)
View official scheme page
https://grants.nih.gov/grants/guide/pa-files/PA-25-303.html
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Last updated: 2026-05-28
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